Margaret Condron


  • Scientific Research Associate II

Ms. Margaret Condron is a very experienced technician who performs peptide synthesis (single and array), RP-HPLC, amino acid analysis, protein sequencing, and mass spectrometry at the Biopolymer Laboratory 

 

Selected Publications:

Condron MM, Monien BH, Bitan G. Synthesis and Purification of Highly Hydrophobic Peptides Derived from the C-Terminus of Amyloid β-Protein. Open Biotechnol J. 2008 Jan 1;2(1):87-93.

 
 

Eric Yale Hayden, Ph.D.


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    Assistant Project Scientist
  • Ph.D. and M.S., Physiology and Biophysics, Albert Einstein College of Medicine of Yeshiva University, 2009
  • B.A., Biology, New York University, 2004

Dr. Eric Yale Hayden is an Assistant Project Scientist in the David Geffen School of Medicine at UCLA, and Brain Research Institute. Dr. Hayden was recognized for his research by receiving the Southern California Alzheimer's Association Young Investigator Award in 2013. Previously, he earned first place postdoctoral researcher in the UCLA Neurology Science poster day, a department consistently ranked #1 or 2 in the nation based on NIH funding. He has a long held interest in understanding protein folding and misfolding, and specifically, its relation to neurodegenerative diseases, including Alzheimer's and Parkinson's disease. He distinguished himself early on by conducting research in high school for which he was selected as a national Semifinalist in the 2000 Intel Science Talent Search. Dr. Hayden’s doctoral thesis focused on studies of the molecular basis for the fibrillation of a-Synuclein, the protein found aggregated into amyloid fibrils in Lewy bodies in Parkinson’s disease (PD) neurons, by using various spectroscopic and analytical methods. He also collaborated widely, including work with an organic chemist, developing small molecules and testing them as drug candidates for possible detection, prevention and/or therapy for PD or Alzheimer’s disease. He currently works with Dr. David Teplow to better understand structure and neurotoxicity relationships of Aβ oligomers.

 

Publications:

1. David Li, Eric Y. Hayden, Koustubh Panda, Dennis J. Stuehr, Haiteng Deng, Denis L. Rousseau and Syun-Ru Yeh.Regulation of the Monomer-Dimer Equilibrium in Inducible Nitric Oxide Synthase by NO. Journal of Biological Chemistry, 2006, 281(12):8197-204. PMID: 16421101.

2. Tsuyoshi Egawa, Jorge Durand, Eric Y. Hayden, Denis L. Rousseau and Syun-Ru Yeh
Design and Evaluation of a Passive Alcove-based Microfluidic Mixer. Analytical Chemistry, 2009, 81 (4), pp 1622–1627. PMID: 19140669

3. Denis L. Rousseau, David Li, Eric Y. Hayden, Haiteng Deng and Syun-Ru Yeh
The Smallest Biomolecules: Diatomics and their Interactions with Heme Proteins. Ligand-Protein Interactions in Nitric Oxide Synthase. Book Chapter, Elsevier Science, Amsterdam. Editor: A. Ghosh. 2008, p235-266. http://www.sciencedirect.com/science/book/9780444528391

4. Eric Y. Hayden and David B. Teplow. Imperial College Press, London. Editor: Philippe Derreumaux.
Alzheimer's disease: Insights into low molecular weight and cytotoxic aggregates from computer simulations: Molecular basis of amyloid β-protein aggregation and fibril formation. Biophysical characterization of Aβ aggregation.
ISBN: 978-1-84816-754-4 and 1-84816-754-7. Pub. Date: Feb 2013.http://www.worldscientific.com/worldscibooks/10.1142/p793

5. Eric Y. Hayden and David B. Teplow
Continuous Flow Reactor for the Production of Stable Amyloid Protein Oligomers.
Biochemistry, 2012, 51(32), 6342-6349. PMID: 22803680

6. Mizwicki MT, Liu G, Fiala M, Magpantay L, Sayre J, Siani A, Mahanian M, Weitzman R, Hayden EY, Rosenthal MJ, Nemere I, Ringman J, Teplow DB.
1α,25-dihydroxyvitamin D3 and resolvin D1 retune the balance between amyloid-β phagocytosis and inflammation in Alzheimer disease patients.Journal of Alzheimer’s Disease, 2012, 34(1). PMID: 23186989

7. Eric Y. Hayden and David B. Teplow
Amyloid β-protein oligomers and Alzheimer's disease.
Alzheimer’s Research and Therapy, 2013, Nov 29;5(6):60. PMID: 24289820

8. Hayden EY, Yamin G, Beroukhim S, Chen B, Kibalchenko M, Jiang L, Ho L, Wang J, Pasinetti GM, Teplow DB. Inhibiting amyloid β-protein assembly: Size-activity relationships among grape seed-derived polyphenols. J Neurochem. 2015 doi: 10.1111/jnc.13270. PMID: 26228682

9. Hayden EY, Kaur P, Williams TL, Matsui H, Yeh SR, Rousseau DL. Heme Stabilization of α-Synuclein Oligomers during Amyloid Fibril Formation. Biochemistry. 2015 Aug 4;54(30):4599-610. doi: 10.1021/acs.biochem.5b00280. Epub 2015 Jul 24. PMID: 26161848

10. Do TD, Lapointe NE, Nelson R, Krotee P, Hayden EY, Ulrich B, Quan, S, Feinstein SC, Teplow DB, Eisenberg D, Shea J-E, Bowers MT. Amyloid β-Protein C-terminal Fragments: Formation of Cylindrins and β-barrels. J Am Chem Soc. 2015 Dec 23. PMID: 26700445

11. Bilousova T, Miller CA, Poon WW, Vinters HV, Corrada M, Kawas C, Hayden EY, Teplow DB, Glabe C, Albay R, Cole GM, Teng E, Gylys KH. Synaptic Aβ oligomers precede p-tau and differentiate high pathology control cases. American Journal of Pathology, 2016 Jan Vol. 186, Issue 1, 185 - 198. Editor’s Choice article. PMID: 26718979

12. Kim B, Do TD, Hayden EY, Teplow DB, Bowers MT, Shea JE. Aggregation of Chameleon Peptides: Implications of α-Helicity in Fibril Formation. J Phys Chem B. 2016 Apr 1. PMID: 27001160

 

Mikhail Kibalchenko, Ph.D.


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    Postdoctoral Scholar
  • Ph.D. Theory of Condensed Matter, University of Cambridge, UK, 2010
  • M.Sci. Physics, Imperial College London, UK, 2006

Dr. Mikhail Kibalchenko is a postdoctoral fellow who is an expert in quantum mechanics and its implementation in understanding protein structure and dynamics. He has combined quantum mechanics with experimental techniques as a powerful interdisciplinary tool to progress scientific knowledge in the structural studies of infinitely disordered chalcogenide glasses, magnetic environments within carbon nanotubes, techniques for distinguishing hydrogen bonding networks, and most recently transport mechanisms in the ADP/ATP mitochondrial transport proteins. In the Teplow laboratory Dr. Kibalchenko is studying the mechanisms of pathogenesis of Alzheimer’s Disease.

Personal research website: http://www.kibalchenko.com/research

 

Publications:

1. M. Kibalchenko, J. R. Yates, C. Massobrio, A. Pasquarello, Structural composition of first-neighbor shells in GeSe2 and GeSe4 glasses from a first-principles analysis of NMR chemical shifts. The Journal of Physical Chemistry C 115 (15), (2011), pp 7755–7759.

2. M. Kibalchenko, M.C. Payne, J.R. Yates. Magnetic response of single-walled carbon nanotubes in- duced by an external magnetic field. ACS Nano Vol. 5, No. 1 (2011), 537–545.

3. M. Kibalchenko, D. Lee, L. Shao, M. C. Payne, J. J. Titman, J. R. Yates. Distinguishing hydrogen bonding networks in alpha-D-galactose using NMR experiments and first principles calculations. Chemical Physics Letters 498 (2010) 270–276.

4. M. Kibalchenko, J. R. Yates, C. Massobrio, A. Pasquarello. Structural assignments of NMR chemical shifts in GexSe{1-x} glasses through first principles calculations for GeSe2, Ge4Se9, and GeSe crystals. Physical Review B (Rapid Communications) 82 (2010) 020202.

5. M. Kibalchenko, J.R. Yates, A. Pasquarello. First principles investigation of the relation between structural and NMR parameters in vitreous GeO2. Journal of Physics: Condensed Matter 22 (2010) 145501.

6. Hayden EY, Yamin G, Beroukhim S, Chen B, Kibalchenko M, Jiang L, Ho L, Wang J, Pasinetti GM, Teplow DB. (2015) Inhibiting amyloid β-protein assembly: Size-activity relationships among grape seed-derived polyphenols. J Neurochem. doi: 10.1111/jnc.13270. PMID: 26228682

7. E.R.S. Kunji, A. Aleksandrova, M.S. King, H. Majd, V.L. Ashton, E. Cerson, R. Springett, M. Kibalchenko, S. Tavoulari, P.G. Crichton, J.J. Ruprecht, (2016). The transport mechanism of the mitochondrial ADP/ATP carrier. Biochimica et Biophysica Acta Molecular Cell Research. doi:10.1016/j.bbamcr.2016.03.015 PMID: 27001633

 

Joseph Conovaloff, B.S.


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    Postgraduate Researcher
  • B.S., Neuroscience, UCLA, 2015

Joseph L. Conovaloff graduated magna cum laude from UCLA with College Honors and Departmental Honors in June 2015 with a bachelor of science in neuroscience and minors in biomedical research and Russian language. Upon graduating, Joseph was inducted into Phi Beta Kappa, the oldest honor society in the United States. He began working in the Teplow laboratory in June 2012 and worked with Dr. Eric Y. Hayden to develop an efficient and successful method of isolating individual oligomers of the amyloid beta-protein. He is now working to characterize these oligomers through various biochemical and biophysical characterization studies. As an undergraduate at UCLA, Joseph participated in many research activities, including the Howard Hughes Undergraduate Research Program, which identifies students who show great promise in the biomedical sciences. For three years, he worked on the Undergraduate Science Journal (USJ) Editorial Board, peer-reviewing research and review articles submitted by undergraduates at UCLA for which he was the Editorial Managing Editor in his senior year. Joseph has won several scholarships and awards for his work, including the UCLA Dean’s Prize as a second-year undergraduate, and he was named a UCLA Undergraduate Research Senior and Junior Scholar. He continues to present his work regularly. Currently, he is a teaching assistant for the UCLA Biomedical Research Minor.

 

Presentations:

1. American Chemical Society Southern California Undergraduate Research Conference, oral presentation (Claremont Colleges), April 2013; poster presentation (Concordia University), April 2014.
2. West Coast Biological Sciences Undergraduate Research Conference, oral presentation (Point Loma Nazarene University), April 2015.
3. UCLA Science Poster Day, Dean’s Prize, May 2013, 2014, and 2015.
4. Neurology Science Poster Day at UCLA, first place undergraduate poster, January 2013.
5. Neuroscience Poster Day at UCLA, winner, May 2014.
6. Minor in Biomedical Research Poster Symposium, May 2013 and August 2014.
7. Summer Programs for Undergraduate Research Poster Day at UCLA, August 2014.

 
 

Parvaneh Shadkam-Farrokhi


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    Undergraduate Researcher

Parvaneh Shadkam-Farrokhi is a third year undergraduate student majoring in Neuroscience and minoring in Biomedical Research at UCLA. She began working in the Teplow Laboratory in February 2014 and is currently working with Dr. Eric Y. Hayden to develop a pathological biomarker for Alzheimer’s Disease by examining cerebrospinal fluid effect on Aβ42 oligomers. She hopes that her research can one day be used to develop an assay system to measure the development of Alzheimer’s Disease and to allow for the early diagnosis of familial Alzheimer’s Disease. Aside from performing research in the Teplow Laboratory, Parvaneh works as a Lab Assistant creating experimental kits for the joint California NanoSystems Institute and IGERT Materials Creation Training Program (MCTP)’s High School Nanoscience Program, allowing high school students to gain exposure to the field of nanoscience involving self- assembly, supercapacitors, solar cells, photolithography, super hydrophobic surfaces, and biotoxicity.

 

 
 

Pei-Yun Tseng


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    Undergraduate Researcher

Pei-Yun Tseng is a fourth year undergraduate at UCLA, majoring in Biochemistry. Her curiosity in protein structures lead her to the lab of ZheFeng Guo during the summer of 2015 to study Yeast Prion morphology using Electron Paramagnetic Resonance. She also examined the aggregation of Amyloid-β protein, which lead to her interest in studying the proximate pathogenic agent, amyloid-β oligomer structures in the Teplow Lab. Under Dr. Eric Y. Hayden’s guidance, she is currently working on understanding the structure-activity relationships of Aβ42 oligomers of specific order.