Dr. Eric Y. Hayden is an Assistant Project Scientist in the Department of Neurology in the David Geffen School of Medicine at the University of California, Los Angeles. He has a long held curiosity in protein folding and misfolding as it relates to neurodegenerative diseases. His research has examined the biophysical and biochemical properties of amyloid forming proteins, and their oligomeric assemblies. Dr. Hayden’s doctoral work focused on studies of the molecular basis of Parkinson’s disease, examining α-synuclein oligomerization, fibrillation and inhibition. In his postdoctoral work he developed a technique to stabilize large quantities of amyloid β-protein (Aβ) oligomers, the protein that has been implicated as a key neurotoxin in Alzheimer’s disease. He also developed a method to isolate individual oligomers in preparation for structure-activity relationship determination. He has also identified important regions of the Aβ sequence through D-amino acid scanning substitutions, and in collaboration with clinicians, is in the process of biomarker development through studies of the ability of cerebrospinal fluid to inhibit oligomerization. In recent work Dr. Hayden is investigating a mixed dementia mouse model to understand the interplay between stroke and Alzheimer’s disease, and has developed methods to dissociate and isolate stroke affected vs. non-affected neuronal populations from mouse cortex for single cell sequencing to pinpoint genes and pathways responsible for responding to neuronal damage.

He has been recognized for his research through awards including pre-doctoral and post-doctoral training grants from the NIH, the Outstanding Young Alumni Award from The Albany Academies, the 2012 Mazz Prize from the UCLA Department of Neurology, a Rapid Grant Award from the UCLA Claude Pepper Older Americans Independence Center and the UCLA Clinical and Translational Science Institute, and the 2013 Young Investigator Award from the California Southland Chapter of the Alzheimer’s Association, and most recently the 2017 Turken Research Award given by the Sam and Ida Turken Charitable Foundation and the Mary S. Easton Center for Alzheimer’s Disease Research at UCLA.

Dr. Hayden received a Bachelor of Arts in Biology from New York University in 2004, and a M.S. and Ph.D. in Physiology and Biophysics from Albert Einstein College of Medicine in 2007 and 2009 respectively. He performed postdoctoral research with David Teplow, Ph.D. in the Department of Neurology at UCLA, and more recently has worked with Jason Hinman, MD, PhD also in the UCLA Department of Neurology.

  • Ph.D. and M.S., Physiology and Biophysics, Albert Einstein College of Medicine of Yeshiva University, 2009
  • B.A., Biology, New York University, 2004
  1. David Li, Eric Y. Hayden, Koustubh Panda, Dennis J. Stuehr, Haiteng Deng, Denis L. Rousseau and Syun-Ru Yeh. Regulation of the Monomer-Dimer Equilibrium in Inducible Nitric Oxide Synthase by NO. Journal of Biological Chemistry, 2006, 281(12):8197-204. PMID: 16421101.
  2. Tsuyoshi Egawa, Jorge Durand, Eric Y. Hayden, Denis L. Rousseau and Syun-Ru Yeh. Design and Evaluation of a Passive Alcove-based Microfluidic Mixer. Analytical Chemistry, 2009, 81 (4), pp 1622–1627. PMID: 19140669
  3. Denis L. Rousseau, David Li, Eric Y. Hayden, Haiteng Deng and Syun-Ru Yeh The Smallest Biomolecules: Diatomics and their Interactions with Heme Proteins. Ligand-Protein Interactions in Nitric Oxide Synthase. Book Chapter, Elsevier Science, Amsterdam. Editor: A. Ghosh. 2008, p235-266. https://www.sciencedirect.com/science/article/pii/B9780444528391500188
  4. Eric Y. Hayden and David B. Teplow. Imperial College Press, London. Editor: Philippe Derreumaux. Alzheimer’s disease: Insights into low molecular weight and cytotoxic aggregates from computer simulations: Molecular basis of amyloid β-protein aggregation and fibril formation. Biophysical characterization of Aβ aggregation. ISBN: 978-1-84816-754-4 and 1-84816-754-7. Pub. Date: Feb 2013. http://www.worldscientific.com/worldscibooks/10.1142/p793
  5. Eric Y. Hayden and David B. Teplow. Continuous Flow Reactor for the Production of Stable Amyloid Protein Oligomers. Biochemistry, 2012, 51(32), 6342-6349. PMID: 22803680
  6. Mizwicki MT, Liu G, Fiala M, Magpantay L, Sayre J, Siani A, Mahanian M, Weitzman R, Hayden EY, Rosenthal MJ, Nemere I, Ringman J, Teplow DB. 1α,25-dihydroxyvitamin D3 and resolvin D1 retune the balance between amyloid-β phagocytosis and inflammation in Alzheimer disease patients. Journal of Alzheimer’s Disease, 2012, 34(1). PMID: 23186989
  7. Hayden EY and Teplow DB Amyloid β-protein oligomers and Alzheimer’s disease. Alzheimer’s Research and Therapy, 2013, Nov 29;5(6):60. PMID: 24289820
  8. Hayden EY, Yamin G, Beroukhim S, Chen B, Kibalchenko M, Jiang L, Ho L, Wang J, Pasinetti GM, Teplow DB. Inhibiting amyloid β-protein assembly: Size-activity relationships among grape seed-derived polyphenols. J Neurochem. 2015 doi: 10.1111/jnc.13270. PMID: 26228682
  9. Hayden EY, Kaur P, Williams TL, Matsui H, Yeh SR, Rousseau DL. Heme Stabilization of α-Synuclein Oligomers during Amyloid Fibril Formation. Biochemistry. 2015 Aug 4;54(30):4599-610. doi: 10.1021/acs.biochem.5b00280. Epub 2015 Jul 24. PMID: 26161848
  10. Do TD, Lapointe NE, Nelson R, Krotee P, Hayden EY, Ulrich B, Quan, S, Feinstein SC, Teplow DB, Eisenberg D, Shea J-E, Bowers MT. Amyloid β-Protein C-terminal Fragments: Formation of Cylindrins and β-barrels. J Am Chem Soc. 2015 Dec 23. PMID: 26700445
  11. Bilousova T, Miller CA, Poon WW, Vinters HV, Corrada M, Kawas C, Hayden EY, Teplow DB, Glabe C, Albay R, Cole GM, Teng E, Gylys KH. Synaptic Aβ oligomers precede p-tau and differentiate high pathology control cases. American Journal of Pathology, 2016 Jan Vol. 186, Issue 1, 185 – 198. Editor’s Choice article. PMID: 26718979
  12. Kim B, Do TD, Hayden EY, Teplow DB, Bowers MT, Shea JE. Aggregation of Chameleon Peptides: Implications of α-Helicity in Fibril Formation. J Phys Chem B. 2016 Apr 1. PMID: 27001160
  13. Hayden EY, Conovaloff JL, Mason A, Bitan G, Teplow DB. Preparation of pure populations of covalently stabilized amyloid β-protein oligomers of specific sizes. Anal Biochem. 2017 Feb 1;518:78-85. PMID: 27810329. PMID: 27810329.
  14. Rentsendorj A, Sheyn J, Fuchs DT, Daley D, Salumbides BC, Schubloom HE, Hart NJ, Li S, Hayden EY, Teplow DB, Black KL, Koronyo Y, Koronyo-Hamaoui M. A novel role for osteopontin in macrophage-mediated amyloid-β clearance in Alzheimer’s models. Brain Behav Immun. 2018 Jan;67:163-180. PMID: 28860067 .
  15. Hayden EY, Hoi KK, Lopez J, Inayathullah M, Condron MM, Teplow DB. Identification of key regions and residues controlling Aβ folding and assembly. Scientific Reports, 2017, Oct 3;7(1):12434. PMID: 28974765. PMID: 28974765.
  16. Banerjee S, Sun Z, Hayden EY, Teplow DB, Lyubchenko YL. Nanoscale Dynamics of Amyloid β-42 Oligomers As Revealed by High-Speed Atomic Force Microscopy. ACS Nano, 2017, Nov 29. PMID: 29165985. PMID: 29165985