Red, red wine: How it fights Alzheimer’s

Researchers discover how compounds found in wine thwart disease in mice

Scientists call it the “French paradox” — a society that, despite consuming food high in cholesterol and saturated fats, has long had low death rates from heart disease. Research has suggested it is the red wine consumed with all that fatty food that may be beneficial — and not only for cardiovascular health but in warding off certain tumors and even Alzheimer’s disease.

 Now, Alzheimer’s researchers at UCLA, in collaboration with Mt. Sinai School of Medicine in New York, have discovered how red wine may reduce the incidence of the disease. Reporting in the Nov. 21 issue of the Journal of Biological Chemistry, David Teplow, a UCLA professor of neurology, and colleagues show how naturally occurring compounds in red wine called polyphenols block the formation of proteins that build the toxic plaques thought to destroy brain cells, and further, how they reduce the toxicity of existing plaques, thus reducing cognitive deterioration.

Polyphenols comprise a chemical class with more than 8,000 members, many of which are found in high concentrations in wine, tea, nuts, berries, cocoa and various plants. Past research has suggested that such polyphenols may inhibit or prevent the buildup of toxic fibers composed primarily of two proteins — Aß40 and Aß42 — that deposit in the brain and form the plaques which have long been associated with Alzheimer’s. Until now, however, no one understood the mechanics of how polyphenols worked.

Teplow’s lab has been studying how amyloid beta (Aß) is involved in causing Alzheimer’s. In this work, researchers monitored how Aß40 and Aß42 proteins folded up and stuck to each other to produce aggregates that killed nerve cells in mice. They then treated the proteins with a polyphenol compound extracted from grape seeds. They discovered that polyphenols carried a one-two punch: They blocked the formation of the toxic aggregates of Aß and also decreased toxicity when they were combined with Aß before it was added to brain cells.

“What we found is pretty straightforward,” Teplow said. “If the Aß proteins can’t assemble, toxic aggregates can’t form, and thus there is no toxicity. Our work in the laboratory, and Mt. Sinai’s Dr. Giulio Pasinetti’s work in mice, suggest that administration of the compound to Alzheimer’s patients might block the development of these toxic aggregates, prevent disease development and also ameliorate existing disease.”

Human clinical trials are next.

“No disease-modifying treatments of Alzheimer’s now exist, and initial clinical trials of a number of different candidate drugs have been disappointing,” Teplow said. “So we believe that this is an important next step.”

This work was supported by the National Institutes of Health; the Department of Veterans Affairs; the James J. Peters Veterans Affairs Medical Center Geriatric Research Education Clinical Center Program, Polyphenolics (to Giulio Pasinetti); grants from the Japan Human Science Foundation and the Mochida Memorial Foundation for Medical and Pharmaceutical Research; grants from the Alzheimer’s Association; and the Jim Easton Consortium for Alzheimer’s Drug Discovery and Biomarkers at UCLA (to David Teplow). Teplow reports no conflict of interests.

The UCLA Department of Neurology encompasses more than a dozen research, clinical and teaching programs that cover brain mapping and neuroimaging, movement disorders, Alzheimer’s disease, multiple sclerosis, neurogenetics, nerve and muscle disorders, epilepsy, neuro-oncology, neurotology, neuropsychology, headaches and migraines, neurorehabilitation, and neurovascular disorders. The department ranks first among its peers nationwide in National Institutes of Health funding.

Contact: Mark Wheeler, 310-794-2265, mwheeler@mednet.ucla.edu

Source: UCLA– University of California, Los Angeles

extenze male enhancement at walmart volume come pills max load volume pills how much are volume pills yellow pills volume 4 rar natural erectile dysfunction pills erectile dysfunction pills from canada erectile dysfunction treatment top pills vitalkmix erectile dysfunction pills otv gnc male enhancement pills side effects male enhancement pills dubai best male enhancement pills with out prescription best male enhancement pills bar none best safest male enhancement pills super hard best sexual male enhancement pills best rapid action herbal sex drive pills erectile dysfunction over the counter pills best 2018 best male fertilitu supplements best supplements for male ejaculation The 7 Best Supplements for Men Male Enhancement Pills best male enhancement supplements drugs like viagra what pill is better than viagra 72hp male enhancement pills best over the counter ed pills top 10 sex pills top 10 penis enlargement pills healthy male enhancement pills 1 male enhancement product what s the best sex pill buy male enhancement what is the best male enhancement supplement pill to help last longer in bed sperm enhancer pills pills to make him last longer in bed safe erection pills over the counter male enhancement cialis can you take viagra with cialis levitra vs cialis review sex and viagra best time to take cialis viagra high sildenafil alternative where to buy viagra for women natural sexual stimulants for males male enhancement plus pinus pills swag sex pills blue male enhancement pills ed products that work natural over the counter viagra where can i get viagra over the counter topical l arginine cream dick inhancer super hard on pills best test supplement hi t testosterone booster gnc hgh supplements testosterone booster with estrogen blocker testfuel make your dick bigger pills extenze supplement herbal male supplement where can i buy zytenz over the counter male arousal drugs penis enhacement passion rx gnc sex pills for couples sizevitrexx complaints plant viagra reviews playboy swx products to increase female sensitivity sex improve medicine men libido how to boost male sex drive over the counter pills like viagra pycnogenol libido ed products online ed med vydox plus vs viagra the best viagra alternative 50mg viagra how long do the effects of levitra last penegra vs viagra medicine works sildenafil dosage for men where can i get viagra fast sugar pills for sale viagra function rhino rx supplement rhino king chinese male enhancement pill herbal viagra pills gnc bio testosterone xr gnc go on red pills reviews big rx plus nenhancer not working dalay pills review buy vigrx what natural herbs are good for erectile dysfunction vigor rx reviews organ supplements penial extension penis enlargement treatments how to naturally make your penis bigger pinus enlarger best penis enlargement methods dick grow proven methods penile growth best penis growth method penis exersize penis extension clinic large penices penis exercises for enlargement 1 cm penis how to make your penis bigger without pills small penid how to make my cock thicker best looking penises i need a bigger penis does testosterone make you bigger penis extender kit penis extension reviews men show their penis which oil is good for penis small erect penis penis pictures of men what is the average penile length for a man average errect penis size what does rlx mean how can you tell a mans penis size average length of a penus rhino 9 pill enduros pills xplode pill black bull pill redotex pills reddit platinum cost double dick reddit viagra maximum dose pills berkeley do fish masturbate what is the average sex time how can i increase my sex power how to increase how much you ejaculate how to keep a man harder longer sex thrusting techniques make sexuality bed healty sex stimulating a man sexually arousing drugs should i take dhea with food does ejaculation raise testosterone vitamins to help sexdrive gnc saudi arabia sexual satisfaction best sex website loss of sex drive in women buy testosterone booster how to get my girlfriend to want me sexually again girl libido best food to increase libido how to rekindle your sex life sexy smoking ladies ml sex woman s or women s use natural ways to boost women s libido how to use sex tablet top 20 sex ashwagandha sex drive how to get the best male ejaculation herbal remedies for sex ayurvedic sex power hamdard unani medicine for erectile dysfunction speman in hindi increase sex power in hindi manforce 50 mg tablets benefits himalaya tentex forte review erection of penis tamil men sex aphrodisiac drugs for male zinc nofap 1dick best buy cialis ginseng for ed how to get rid of viagra headache pills to stop feelings i want do sex sex of men with men i want men plesure intercourse process natural way to stay hard where can i find a man abs diet mens health amazing sex tips for him why webmd is bad duration for men foreplays tips for him with pictures men sex

  • does diet coke raise your blood sugar
  • diet coke raise blood sugar
  • do tomatoes raise-your blood sugar
  • normal blood sugar waking up
  • what can lower blood sugar fast
  • smart blood sugar book used
  • testing blood sugar at home without pricking finger
  • is 222 high for blood sugar
  • is baking soda good for blood sugar
  • average blood sugar after a meal
  • insulin for high blood sugar
  • walnuts lower blood sugar
  • 124 blood sugar
  • chia seeds and blood sugar levels
  • blood sugar 438
  • does eating rice raise blood sugar
  • perfect blood sugar numbers
  • why does my blood sugar spike at night
  • chia seeds blood sugar
  • blood sugar 145 in morning
  • blood sugar 77 two hours after eating
  • does apple cider vinegar bring down blood sugar
  • can drinking water lower your blood sugar
  • is 98 a good blood sugar level
  • is 160 good for blood sugar
  • how does diet coke affect blood sugar
  • 61 blood sugar
  • does honey spike blood sugar
  • 133 blood sugar in the morning
  • does elevated blood sugar make you sleepy
  • blood sugar and kidney disease
  • blood sugar 141
  • expired blood sugar strips
  • range of normal blood sugar
  • does green cabbage lower blood sugar
  • 184 blood sugar after eating
  • smoothie to lower blood sugar
  • apple watch with blood sugar monitor
  • blood sugar 278
  • blood sugar 141 after meal
  • what is a normal blood sugar rating
  • monitoring blood sugar levels for weight loss
  • does your blood sugar increase after exercise
  • normal blood sugar two hours after meal
  • is 72 normal blood sugar level
  • best time to test your blood sugar
  • how to improve fasting blood sugar levels
  • apple cider lower blood sugar
  • how does beer affect blood sugar
  • blood sugar after quitting smoking
  • average blood sugar a1c chart