Publication Article – Teplow Lab Neurology UCLA

Publications * (Selected peer-reviewed publications)

Rentsendorj A, Sheyn J, Fuchs DT, Daley D, Salumbides BC, Schubloom HE, Hart NJ, Li S, Hayden EY, Teplow DB, Black KL, Koronyo Y, Koronyo-Hamaoui M. (2018) A novel role for osteopontin in macrophage-mediated amyloid-β clearance in Alzheimer’s models. Brain Behav Immun. 67:163-180. PMID: 28860067. PMID: 28860067 .
Hayden EY, Hoi KK, Lopez J, Inayathullah M, Condron MM, Teplow DB. (2017) Identification of key regions and residues controlling Aβ folding and assembly. Scientific Reports, 7(1):12434. PMID: 28974765. PMID: 28974765.
Banerjee S, Sun Z, Hayden EY, Teplow DB, Lyubchenko YL. (2017) Nanoscale Dynamics of Amyloid β-42 Oligomers As Revealed by High-Speed Atomic Force Microscopy. ACS Nano. PMID: 29165985. PMID: 29165985.
Kim B, Do TD, Hayden EY, Teplow DB, Bowers MT, Shea JE. (2016) Aggregation of Chameleon Peptides: Implications of α-Helicity in Fibril Formation. J Phys Chem B. 2016 Apr 1. PMID: 27001160
Hayden EY, Conovaloff JL, Mason A, Bitan G, Teplow DB. (2017) Preparation of pure populations of covalently stabilized amyloid β-protein oligomers of specific sizes. Anal Biochem.518:78-85. PMID: 27810329. PMID: 27810329 .
Roychaudhuri R, Zheng X, Lomakin A, Maiti P, Condron MM, Benedek GB, Bitan G, Bowers MT, Teplow DB. (2015) Role of Species-Specific Primary Structure Differences in Aβ42 Assembly and Neurotoxicity. ACS Chem Neuroscience. doi: 10.1021/acschemneuro.5b00180. PMID: 26421877
Hayden EY, Yamin G, Beroukhim S, Chen B, Kibalchenko M, Jiang L, Ho L, Wang J, Pasinetti GM, Teplow DB. (2015) Inhibiting amyloid β-protein assembly: Size-activity relationships among grape seed-derived polyphenols. J Neurochem. doi: 10.1111/jnc.13270. PMID: 26228682
Yamin G, Huynh TV, Teplow DB. (2015) Design and characterization of chemically stabilized Aβ42 oligomers. Biochemistry. doi: 10.1021/acs.biochem.5b00318 PMID: 26241378
Roychaudhuri R, Lomakin A, Bernstein S, Zheng X, Condron MM, Benedek GB, Bowers MT, and Teplow DB (2014) Gly25-Ser26 amyloid β-protein structural isomorphs produce distinct Aβ42 conformational dynamics and assembly characteristics. J Mol Biol, 426:2422–2441. PMID:24735871
Roychaudhuri R, Yang M, Deshpande A, Cole GM, Frautschy S, Lomakin A, Benedek GB, Teplow DB.(2013) C-Terminal Turn Stability Determines Assembly Differences between Aβ40 and Aβ42. JMB, 425:292–308. PMID: 23154165
Hayden EY and Teplow DB. (2012) Continuous Flow Reactor for the Production of Stable Amyloid Protein Oligomers. Biochemistry, 51(32), 6342-6349. PMID: 22803680
Roychaudhuri R, Yang M, Condron MM, Teplow DB. (2012) Structural dynamics of the amyloid β-protein monomer folding nucleus.Biochemistry. May 15;51(19):3957-9. PMID: 22551351
Inayathullah M and Teplow DB (2011) Structural dynamics of the ΔE22 (Osaka) familial Alzheimer’s disease-linked amyloid β-protein. Amyloid: J. Prot. Fold. Dis., in press. PMID: 21668291
Matsumura S, Shinoda K, Yamada M, Yokojima S, Inoue M, Ohnishi T, Shimada T, Kikuchi K, Masui D, Hashimoto S, Sato M, Ito A, Akioka M, Takagi S, Nakamura Y, Nemoto K, Hasegawa Y, Takamoto H, Inoue H, Nakamura S, Nabeshima Y, Teplow DB, Kinjo M, and Hoshi M (2011) Two distinct amyloid β-protein (Aβ) assembly pathways leading to oligomers and fibrils identified by combined fluorescence correlation spectroscopy, morphology and toxicity analyses. JBC, 286:11555-11562. PMID: 21292768; PMCID: PMC3064209
Ono K, Condron MM, and Teplow DB (2010) Effects of the English (H6R) and Tottori (D7N) familial Alzheimer disease mutations on amyloid β-protein assembly and toxicity. JBC, 285:23186-23197. PMID: 20452980; PMCID: PMC2906312
Wang J, Santa-Maria I, Ho L, Ksiezak-Reding H, Ono K, Teplow DB, Pasinetti GM (2010) Grape-derived polyphenols attenuate tau neuropathology in a mouse model of Alzheimer’s disease. J Alzheimer’s Dis, 22:653-661. PMID: 20858961
Urbanc B, Betnel M, Cruz L, Bitan G, Teplow DB (2010) Elucidation of amyloid β-protein oligomerization mechanisms: Discrete molecular dynamics study. JACS, 132:4266-4280. PMID: 20218566
Ikeda T, Ono K, Elashoff D, Condron MM, Noguchi-Shinohara M, Yoshita M, Teplow DB, and Yamada M (2010) Cerebrospinal fluid of Alzheimer patients promotes amyloid β-protein oligomerization. J Alzheimer’s Dis, 21:81-86. PMID: 20413863
Walsh DM, Thulin E, Minogue AM, Gustavsson N, Pang E, Teplow DB, Linse S (2009) Aβ facile method for expression and purification of the Alzheimer’s disease-associated amyloid β-peptide. FEBS J, 276:1266-1281. PMID: 19175671; PMCID: PMC2702495
Yamin G, Ruchala P, Teplow DB (2009) A peptide hairpin inhibitor of amyloid β-protein oligomerization and fibrillogenesis. Biochem, 48:11329-11331. PMID: 19877710
Noguchi A, Matsumura S, Dezawa M, Tada M, Yanazawa M, Ito A, Akioka M, Kikuchi S, Sato M, Ideno S, Noda M, Fukunari A, Muramatsu S, Itokazu Y, Sato K, Takahashi H, Teplow DB, Nabeshima Y, Kakita A, Imahori K, and Hoshi M (2009) Isolation and characterization of patient-derived, toxic, high-mass amyloid β-protein (Aβ) assembly from Alzheimer disease brains. J Biol Chem, 284:32895-32905. PMID: 19759000; PMCID: PMC2781705
Maji SK, Ogorzalek Loo RR, Spring SM, Vollers SS, Condron MM, Bitan G, Loo JA, and Teplow DB (2009) Amino acid position-specific contributions to amyloid β-protein oligomerization. J Biol Chem, 284:23580-23591. PMID: 19567875; PMCID: PMC2749133
Ono K, Condron MM, Teplow DB (2009) Structure-neurotoxicity relationships of amyloid β-protein oligomers. PNAS, 106:14745-14750. PMID: 19706468; PMCID: PMC2736424
Murray M, Bernstein S, Nyugen V, Condron MM, Teplow D, Bowers M (2009) Amyloid β-protein: Aβ40 inhibits Aβ42 oligomerization. JACS, 131:6316-6317. PMID: 19385598; PMCID: PMC2697393
Bernstein SL, Dupuis NF, Lazo ND, Wyttenbach T, Condron MM, Bitan G, Teplow DB, Shea J-E, Ruotolo BT, Robinson CV & Bowers MT (2009) Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer’s disease. Nature Chem, 1: 326-331. PMID: 20703363; PMCID: PMC2918915
Murray M, Krone MG, Bernstein SL, Baumketner A, Condron, M, Lazo ND, Teplow DB, Wyttenbach T, Shea J-E, Bowers MT (2009) Amyloid β-protein: Experiment and theory on the 21-30 fragment. J Phys Chem B, 113: 6041-6046. PMID: 19341254; PMCID: PMC2693341
Zaghi J, Goldenson B, Inayathullah M, Lossinsky AS, Masoumi A, Avagyan H, Mahanian M, Bernas M, Weinand M, Rosenthal MJ, Espinosa-JeVrey A, De Vellis JS, Teplow DB, Fiala M (2009) Alzheimer disease macrophages shuttle amyloid-β from neurons to vessels, contributing to amyloid angiopathy. Acta Neuropathol, 117:111-124. PMID: 19139910
Ho L, Chen LH, Wang J, Zhao W, Talcott ST, Ono K, Teplow DB, Humala N, Cheng A, Percival SS, Ferruzzi M, Janle E, Weaver C, Dickstein DL, Pasinetti GM (2009) Heterogeneity in red wine polyphenolic contents differentially influences Alzheimer’s disease-type neuropathology and cognitive deterioration. J Alzheimer’s Dis, 16:59-72. PMID: 19158422; PMCID: PMC2857553
Zhao W, Wang J, Ho, L, Ono K, Teplow DB, Pasinetti GM (2009) Identification of antihypertensive drugs which inhibit amyloid-β protein oligomerization. J Alzheimer’s Dis, 16:49-57. PMID: 19158421
Lam AR, Teplow DB, Stanley HE, and Urbanc B (2008) Effects of the Arctic (Glu22->Gly) mutation on amyloid β-protein folding: Discrete molecular dynamics study. JACS, 130:17413-17422. PMID: 19053400
Ono K, Condron MM, Ho L, Wang J, Zhao W, Pasinetti GM, and Teplow DB (2008) Effects of grape seed-derived polyphenols on amyloid β-protein self-assembly and cytotoxicity. J. Biol Chem, 283: 32176-32187. (This paper was selected as a JBC “Paper of the Week,” an honor accorded to papers in the top 1% of all published, based on significance and overall importance.) PMID: 18815129; PMCID: PMC2583320
Yang M and Teplow DB (2008) Amyloid β-protein monomer folding: free energy landscapes reveal alloform specific differences. J Mol Biol, 384: 450-464. PMID: 18835397; PMCID: PMC2673916
Fluhrer R, Fukumori A, Martin L, Grammer G, Haug-Kröperr M, Klier B, Winkler E, Kremmer E, Condron MM, Teplow DB, Steiner H, and Haass C (2008) Intramembrane proteolysis of GxGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation. J Biol Chem, 283: 30121-30128. PMID: 18768471; PMCID: PMC2573083
Wang J, Ho L, Zhao W, Ono K, Rosensweig C, Chen L, Humala N, Teplow DB, Pasinetti GM (2008) Grape-derived polyphenolics prevent Aβ oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer’s disease. J Neurosci, 28: 6388-6392. PMID: 18562609; PMCID: PMC2806059
Krone MG, Baumketner A, Bernstein SL, Wyttenbach T, Lazo ND, Teplow DB, Bowers MT, Shea J-E (2008) Effects of familial Alzheimer’s disease mutations on the folding nucleation of the amyloid β-protein. J Mol Biol, 381: 221-228. PMID: 18597778; PMCID: PMC2597412
Ren Y, Strobel GA, Graff JC, Jutila M, Park SG, Gosh S, Teplow D, Condron M, Pang E, Hess WM, and Moore E (2008) Colutellin A, an immunosuppressive peptide from Colletotrichum dematium. Microbiology, 154: 1973-1979. PMID: 18599825
Grant MA, Lazo ND, Lomakin A, Condron MM, Arai H, Yamin G, Rigby AC, and Teplow DB (2007) Familial Alzheimer’s disease mutations alter the stability of the amyloid β-protein monomer folding nucleus. PNAS, 104: 16522-16527. PMID: 17940047; PMCID: PMC2034231
Yun S, Urbanc B, Cruz L, Bitan G, Teplow DB, Stanley HE (2007) Role of electrostatic interactions in amyloid β-protein (A β) oligomer formation: a discrete molecular dynamics study. Biophys J, 92:4064-4077. PMID: 17307823; PMCID: PMC1868995
Hori Y, Hashimoto T, Wakutani Y, Urakami K, Nakashima K, Condron MM, Tsubuki S, Saido TC, Teplow DB, and Iwatsubo T. (2007) The Tottori (D7N) and English (H6R) familial Alzheimer’s disease mutations accelerate Aβ fibril formation without increasing protofibril formation. J Biol Chem, 282:4916-4923. PMID: 17170111